Endometriosis is a puzzling disease affecting women in their reproductive years. The name comes from the word "endometrium," which is the tissue that lines the inside of the uterus and builds up and sheds each month in the menstrual cycle. In endometriosis, tissue like the endometrium is found outside the uterus, in other areas of the body.
In these locations outside the uterus, the endometrial tissue develops into what are called "nodules," "tumors," "lesions," "implants," or "growths." These growths can cause pain, infertility, and other problems.
The most common locations of endometrial growths are in the abdomen-involving the ovaries, fallopian tubes, the ligaments supporting the uterus, the area between the vagina and the rectum, the outer surface of the uterus, and the lining of the pelvic cavity. Sometimes the growths are also found in abdominal surgery scars, on the intestines or in the rectum, on the bladder, vagina, cervix, and vulva (external genitals).
Endometrial growths have also been found outside the abdomen, in the lung, arm, thigh, and other locations, but these are uncommon. Endometrial growths are generally not malignant or cancerous, they are a type of normal type of tissue outside the normal location.
However, in recent decades there has been an increased frequency of malignancy occurring or being recognized in conjunction with endometriosis. Like the lining of the uterus, endometrial growths usually respond to the hormones of the menstrual cycle. They build up tissue each month, break down, and cause bleeding.
Unlike tissue within the lining of the uterus, endometrial tissue outside the uterus has no way of leaving the body. The result is internal bleeding, degeneration of the blood and tissue shed from the growths, inflammation of the surrounding areas, and formation of scar tissue.
Other complications, depending on the location of the growths, can be rupture of growths (which can spread endometriosis to new areas), the formation of adhesions, intestinal bleeding or obstruction (if the growths are in or near the intestines), interference with bladder function (if the growths are on or in the bladder), and other problems. Symptoms seem to worsen with time, though cycles of remission and reoccurrence are the pattern in some cases.
Could You Have Endometriosis ?
The most common symptoms of endometriosis are pain before and during periods (usually worse than "normal" menstrual cramps), during or after sexual activity, infertility, and heavy or irregular bleeding.
Other symptoms may include fatigue; painful bowel movements with periods; lower back pain with periods; diarrhea and/or constipation and other intestinal upset with some periods.
Some women with endometriosis have no symptoms. Infertility affects about 30-40% of women with endometriosis and is a common result with progression of the disease.
The amount of pain is not necessarily related to the extent or size of growths. Tiny growths (called"petechial") have been found to be more active in producing prostaglandins, which may explain the significant symptoms that often seem to occur with small implants. Prostaglandins are substances produced throughout the body, involved in numerous functions, and thought to cause many of the symptoms of endometriosis.
Theories About the Cause of Endometriosis
The cause of endometriosis is not known. A number of theories have been advanced but no one of them seems to account for all cases.
One theory is the retrograde menstruation or transtubal migration theory that during menstruation some of the menstrual tissue backs up through the fallopian tubes, implants in the abdomen, and grows. Some experts on endometriosis believe all women experience some menstrual tissue backup and that an immune system problem and/or hormonal problem allows this tissue to take root and grow in women who develop endometriosis.
Another theory suggests that the endometrial tissue is distributed from the uterus to other parts of the body through the Lymph system or the blood system. A genetic theory suggests that it may be carried in the genes of certain families or that certain families may have predisposing factors to endometriosis
Still another theory suggests that remnants of tissue from when the woman was an embryo may later develop into endometriosis or that some adult tissues retain the ability they had in the embryo stage to transform into reproductive tissue under certain circumstances. Surgical transplantation has also been cited as a cause in cases where endometriosis is found in abdominal surgery scars, although it has also been found in such scars when direct accidental implantation seems unlikely. Other theories are being developed by the Association and others researching endometriosis.
Diagnosing Endometriosis Diagnosis of endometriosis is generally considered uncertain until proven by laparoscopy. Laparoscopy is a minor surgical procedure done under anesthesia in which the patient's abdomen is distended with carbon dioxide gas to make the organs easier to see and a laparoscope (a tube with a light in it) is inserted into a tiny incision in the abdomen.
By moving the laparoscope around the abdomen, the surgeon can check the condition of the abdominal organs and see the endometrial implants, if care and thoroughness are used.
A doctor can often feel the endometrial implants upon palpation (pelvic examination by the doctor's hands), and symptoms will often indicate endometriosis, but medical textbooks indicate it is not good practice to treat this disease without confirmation of the diagnosis.
Ovarian cancer sometimes has the same symptoms as endometriosis, and hormonal treatment (particularly estrogen), which is common in treating endometriosis, could cause a cancer to grow even faster.
A laparoscopy also indicates the locations, extent, and size of the growths and may help the doctor and patient make better informed, long-range decisions about treatment and pregnancy.
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